Description

Buy Α-Pyrrolidinopentiophenone; Α-PVP; O-2387,A-PVP C15H21NO Online

CAS NO.:5485-65-4 Α-Pyrrolidinopentiophenone; Α-PVP;O-2387,A-PVP C15H21NO Recreational Club Clinical Composite Psychoactive Aphrodisiac Designer Drug

Detail：

        α-Pyrrolidinopentiophenone (also known as α-pyrrolidinovalerophenone, α-PVP, O-2387, β-keto-prolintane, prolintanone, or desmethylpyrovalerone) is a synthetic stimulant of the cathinone class developed in the 1960s that has been sold as a designer drug. Colloquially, it is sometimes called flakka. α-PVP is chemically related to pyrovalerone and is the ketone analog of prolintane.

Adverse effects：

        α-PVP, like other psychostimulants, can cause hyperstimulation, paranoia, and hallucinations. α-PVP has been reported to be the cause, or a significant contributory cause of death in suicides and overdoses caused by combinations of drugs. α-PVP has also been linked to at least one death with pulmonary edema and moderately advanced atherosclerotic coronary disease when it was combined with pentedrone.

Pharmacology：

        α-PVP acts as a norepinephrine-dopamine reuptake inhibitor with IC50 values of 14.2 and 12.8 nM, respectively, similar to its methylenedioxy derivative MDPV. Similar to other cathinones, α-PVP has been shown to have reinforcing effects in rats.

Chemistry：

        α-PVP gives no reaction with the marquis reagent. It gives a grey/black reaction with the mecke reagent.

Detection in body fluids：

        α-PVP may be quantified in blood, plasma or urine by liquid chromatography-mass spectrometry to confirm a diagnosis of poisoning in hospitalized patients or to provide evidence in a medicolegal death investigation. Blood or plasma α-PVP concentrations are expected to be in a range of 10–50 μg/L in persons using the drug recreationally, >100 μg/L in intoxicated patients and >300 μg/L in victims of acute overdosage.

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